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<table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">TCF3</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class=""><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P15806%20or%20P15923%20or%20K7EK65">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P15806,P15923,K7EK65">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2MH0">2MH0</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2YPA">2YPA</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2YPB">2YPB</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3U5V">3U5V</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class=""><a href="Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/11633">TCF3</a></span>, E2A, E47, ITF1, TCF-3, VDIR, bHLHb21, AGM8, transcription factor 3, p75</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a href="Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/147141">147141</a>; <a href="Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:98510">98510</a>; <a href="HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=2408">2408</a>; <a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=TCF3">TCF3</a>; <a href="Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000071564">TCF3 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a href="Chromosome_19_(human)" class="mw-redirect" title="Chromosome 19 (human)">Chromosome 19 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"></span><div style="position: absolute; left: 2.7838164009775px; top: 2px; padding: 0;"><span typeof="mw:File"></span></div><div style="position: absolute; left: 8.8px; top: 19px; padding: 0;"><span typeof="mw:File"></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">19p13.3</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">1,609,290 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">1,652,605 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">Chromosome 10 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"></span><div style="position: absolute; left: 175.22184027671px; top: 2px; padding: 0;"><span typeof="mw:File"></span></div><div style="position: absolute; left: 181.2px; top: 19px; padding: 0;"><span typeof="mw:File"></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">10 C1|10 39.72 cM</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">80,245,348 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">80,269,481 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="Human_genome" title="Human genome">Human</a></b></th><th><b><a href="Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000071564">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">ganglionic eminence</li><br><li style="line-height: 137%;">ventricular zone</li><br><li style="line-height: 137%;">right testis</li><br><li style="line-height: 137%;">left testis</li><br><li style="line-height: 137%;">pancreatic ductal cell</li><br><li style="line-height: 137%;">lymph node</li><br><li style="line-height: 137%;">bone marrow cell</li><br><li style="line-height: 137%;">gonad</li><br><li style="line-height: 137%;">appendix</li><br><li style="line-height: 137%;">stromal cell of endometrium</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000020167">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">ventricular zone</li><br><li style="line-height: 137%;">genital tubercle</li><br><li style="line-height: 137%;">tail of embryo</li><br><li style="line-height: 137%;">mandibular prominence</li><br><li style="line-height: 137%;">maxillary prominence</li><br><li style="line-height: 137%;">lip</li><br><li style="line-height: 137%;">epiblast</li><br><li style="line-height: 137%;">somite</li><br><li style="line-height: 137%;">abdominal wall</li><br><li style="line-height: 137%;">yolk sac</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000071564">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span><br><br><span typeof="mw:File"></span><br><br><span typeof="mw:File"></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="http://biogps.org/gene/6929/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">
<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003677">DNA binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043565">sequence-specific DNA binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046983">protein dimerization activity</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042803">protein homodimerization activity</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003700">DNA-binding transcription factor activity</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031435">mitogen-activated protein kinase kinase kinase binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070644">vitamin D response element binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003713">transcription coactivator activity</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008134">transcription factor binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000978">RNA polymerase II cis-regulatory region sequence-specific DNA binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001227">DNA-binding transcription repressor activity, RNA polymerase II-specific</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043425">bHLH transcription factor binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070888">E-box binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046982">protein heterodimerization activity</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000981">DNA-binding transcription factor activity, RNA polymerase II-specific</a></li></ul>
</div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">
<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005667">transcription regulator complex</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0090575">RNA polymerase II transcription regulator complex</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016607">nuclear speck</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032991">protein-containing complex</a></li></ul>
</div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">
<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030154">cell differentiation</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006355">regulation of transcription, DNA-templated</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051149">positive regulation of muscle cell differentiation</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051091">positive regulation of DNA-binding transcription factor activity</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000122">negative regulation of transcription by RNA polymerase II</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006351">transcription, DNA-templated</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007399">nervous system development</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045893">positive regulation of transcription, DNA-templated</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000045">regulation of G1/S transition of mitotic cell cycle</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002326">B cell lineage commitment</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045787">positive regulation of cell cycle</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030890">positive regulation of B cell proliferation</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045666">positive regulation of neuron differentiation</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030183">B cell differentiation</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033152">immunoglobulin V(D)J recombination</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045944">positive regulation of transcription by RNA polymerase II</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1902036">regulation of hematopoietic stem cell differentiation</a></li></ul>
</div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=6929&rn=1">6929</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=21423&rn=1">21423</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000071564;db=core">ENSG00000071564</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000020167;db=core">ENSMUSG00000020167</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P15923">P15923</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P15806">P15806</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001136139">NM_001136139</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_003200">NM_003200</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001351778">NM_001351778</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001351779">NM_001351779</a></span></p></td></tr></tbody></table></td><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001164147">NM_001164147</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001164148">NM_001164148</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001164149">NM_001164149</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001164150">NM_001164150</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001164151">NM_001164151</a><br></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001164152">NM_001164152</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001164153">NM_001164153</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_011548">NM_011548</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001378903">NM_001378903</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001378904">NM_001378904</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001378905">NM_001378905</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001378908">NM_001378908</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001378910">NM_001378910</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001378912">NM_001378912</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001378913">NM_001378913</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001378914">NM_001378914</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001129611">NP_001129611</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_003191">NP_003191</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001338707">NP_001338707</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001338708">NP_001338708</a></span></p></td></tr></tbody></table></td><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001157619">NP_001157619</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001157620">NP_001157620</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001157621">NP_001157621</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001157622">NP_001157622</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001157623">NP_001157623</a><br></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001157624">NP_001157624</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001157625">NP_001157625</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_035678">NP_035678</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001365832">NP_001365832</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001365833">NP_001365833</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001365834">NP_001365834</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001365837">NP_001365837</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001365839">NP_001365839</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001365841">NP_001365841</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001365842">NP_001365842</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001365843">NP_001365843</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class=""><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr19:1609290-1652605">Chr 19: 1.61 – 1.65 Mb</a></span></td><td><span class=""><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr10:80245348-80269481">Chr 10: 80.25 – 80.27 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="PubMed" title="PubMed">PubMed</a> search</th><td><span class=""><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class=""><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18031869" class="extiw external" title="d:Q18031869">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18254841" class="extiw external" title="d:Q18254841">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table>
<p><b>Transcription factor 3</b> (<b>E2A immunoglobulin enhancer-binding factors E12/E47</b>), also known as <b>TCF3</b>, is a <a href="Protein" title="Protein">protein</a> that in humans is encoded by the <i>TCF3</i> <a href="Gene" title="Gene">gene</a>.<sup id="cite_ref-entrez_6929_5-0" class="reference"><a href="#cite_note-entrez_6929-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid2308859_6-0" class="reference"><a href="#cite_note-pmid2308859-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid1967983_7-0" class="reference"><a href="#cite_note-pmid1967983-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> TCF3 has been shown to directly enhance Hes1 (a well-known target of <a href="Notch_signaling" class="mw-redirect" title="Notch signaling">Notch signaling</a>) expression.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup>
</p>
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<div class="mw-heading mw-heading2"><h2 id="Function">Function</h2></div>
<p>This gene encodes a member of the E protein (class I) family of <a href="Helix-loop-helix" class="mw-redirect" title="Helix-loop-helix">helix-loop-helix</a> <a href="Transcription_factor" title="Transcription factor">transcription factors</a>. The 9aaTAD transactivation domains of E proteins and MLL are very similar and both bind to the <a href="KIX_domain" title="KIX domain">KIX domain</a> of general transcriptional mediator CBP.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for the <a href="B_lymphocyte" class="mw-redirect" title="B lymphocyte">B</a> and <a href="T_lymphocyte" class="mw-redirect" title="T lymphocyte">T lymphocyte</a> development.<sup id="cite_ref-entrez_6929_5-1" class="reference"><a href="#cite_note-entrez_6929-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
</p><p><span typeof="mw:File"></span>
<span typeof="mw:File"></span>
</p><p>This gene regulates many developmental patterning processes such as lymphocyte and central nervous system (CNS) development. E proteins are involved in the development of lymphocytes.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> They initiate transcription by binding to regulatory E-box sequences on target genes.
</p>
<div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2></div>
<p>Deletion of this gene or diminished activity of the encoded protein may play a role in <a href="Lymphoid" class="mw-redirect" title="Lymphoid">lymphoid</a> malignancies. This gene is also involved in several <a href="Chromosomal_translocation" title="Chromosomal translocation">chromosomal translocations</a> that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1 and t(17;19), with HLF),<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384).<sup id="cite_ref-entrez_6929_5-2" class="reference"><a href="#cite_note-entrez_6929-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2></div>
<p>TCF3 has been shown to <a href="Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with:
</p>
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<ul><li><a href="CBFA2T3" title="CBFA2T3">CBFA2T3</a>,<sup id="cite_ref-pmid16407974_13-0" class="reference"><a href="#cite_note-pmid16407974-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup></li>
<li><a href="CREB-binding_protein" title="CREB-binding protein">CREBBP</a>,<sup id="cite_ref-pmid12435739_14-0" class="reference"><a href="#cite_note-pmid12435739-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li>
<li><a href="ELK3" title="ELK3">ELK3</a>,<sup id="cite_ref-pmid8918463_15-0" class="reference"><a href="#cite_note-pmid8918463-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup></li>
<li><a href="EP300" title="EP300">EP300</a>,<sup id="cite_ref-pmid12435739_14-1" class="reference"><a href="#cite_note-pmid12435739-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li>
<li><a href="ID3_(gene)" title="ID3 (gene)">ID3</a>,<sup id="cite_ref-pmid9525934_16-0" class="reference"><a href="#cite_note-pmid9525934-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9242638_17-0" class="reference"><a href="#cite_note-pmid9242638-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup></li>
<li><a href="LDB1" title="LDB1">LDB1</a>,<sup id="cite_ref-pmid16407974_13-1" class="reference"><a href="#cite_note-pmid16407974-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup></li>
<li><a href="LMX1A" title="LMX1A">LMX1A</a>,<sup id="cite_ref-pmid9199284_18-0" class="reference"><a href="#cite_note-pmid9199284-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup></li>
<li><a href="LYL1" title="LYL1">LYL1</a>,<sup id="cite_ref-pmid8628307_19-0" class="reference"><a href="#cite_note-pmid8628307-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup></li>
<li><a href="MAPKAPK3" title="MAPKAPK3">MAPKAPK3</a>,<sup id="cite_ref-pmid10781029_20-0" class="reference"><a href="#cite_note-pmid10781029-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup></li>
<li><a href="MyoD" title="MyoD">MyoD</a>,<sup id="cite_ref-pmid9242638_17-1" class="reference"><a href="#cite_note-pmid9242638-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9184158_21-0" class="reference"><a href="#cite_note-pmid9184158-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup></li>
<li><a href="Myogenin" title="Myogenin">Myogenin</a>,<sup id="cite_ref-pmid9242638_17-2" class="reference"><a href="#cite_note-pmid9242638-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid1325437_22-0" class="reference"><a href="#cite_note-pmid1325437-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup></li>
<li><a href="PCAF" title="PCAF">PCAF</a>,<sup id="cite_ref-pmid12435739_14-2" class="reference"><a href="#cite_note-pmid12435739-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li>
<li><a href="TAL1" title="TAL1">TAL1</a><sup id="cite_ref-pmid16407974_13-2" class="reference"><a href="#cite_note-pmid16407974-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8159721_23-0" class="reference"><a href="#cite_note-pmid8159721-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup></li>
<li><a href="Twist_transcription_factor" class="mw-redirect" title="Twist transcription factor">TWIST1</a>,<sup id="cite_ref-pmid10749989_24-0" class="reference"><a href="#cite_note-pmid10749989-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> and</li>
<li><a href="UBE2I" title="UBE2I">UBE2I</a>.<sup id="cite_ref-pmid10497239_25-0" class="reference"><a href="#cite_note-pmid10497239-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup></li></ul>
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<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>
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<li id="cite_note-pmid1325437-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid1325437_22-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFChakrabortyMartinOlson1992" class="citation journal cs1">Chakraborty T, Martin JF, Olson EN (September 1992). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2819%2937069-3">"Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system"</a>. <i>The Journal of Biological Chemistry</i>. <b>267</b> (25): <span class="nowrap">17498–</span>17501. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2819%2937069-3">10.1016/S0021-9258(19)37069-3</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1325437">1325437</a>.</cite></span>
</li>
<li id="cite_note-pmid8159721-23"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid8159721_23-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFHsuWadmanBaer1994" class="citation journal cs1">Hsu HL, Wadman I, Baer R (April 1994). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43539">"Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>91</b> (8): <span class="nowrap">3181–</span>3185. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1994PNAS...91.3181H">1994PNAS...91.3181H</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.91.8.3181">10.1073/pnas.91.8.3181</a></span>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43539">43539</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8159721">8159721</a>.</cite></span>
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<li id="cite_note-pmid10749989-24"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10749989_24-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFEl_GhouzziLegeai-MalletArestaBenoist2000" class="citation journal cs1">El Ghouzzi V, Legeai-Mallet L, Aresta S, Benoist C, Munnich A, de Gunzburg J, et al. (March 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2F9.5.813">"Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location"</a>. <i>Human Molecular Genetics</i>. <b>9</b> (5): <span class="nowrap">813–</span>819. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2F9.5.813">10.1093/hmg/9.5.813</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10749989">10749989</a>.</cite></span>
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<li id="cite_note-pmid10497239-25"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10497239_25-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFHugginsChinSibingaLee1999" class="citation journal cs1">Huggins GS, Chin MT, Sibinga NE, Lee SL, Haber E, Lee ME (October 1999). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.274.40.28690">"Characterization of the mUBC9-binding sites required for E2A protein degradation"</a>. <i>The Journal of Biological Chemistry</i>. <b>274</b> (40): <span class="nowrap">28690–</span>28696. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.274.40.28690">10.1074/jbc.274.40.28690</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10497239">10497239</a>.</cite></span>
</li>
</ol></div>
<div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2></div>
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<ul><li><cite id="CITEREFLeBrun2003" class="citation journal cs1">LeBrun DP (May 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.2741%2F1030">"E2A basic helix-loop-helix transcription factors in human leukemia"</a>. <i>Frontiers in Bioscience</i>. <b>8</b> (<span class="nowrap">1–</span>3): <span class="nowrap">s206 –</span> <span class="nowrap">s222</span>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.2741%2F1030">10.2741/1030</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12700034">12700034</a>.</cite></li></ul>
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</style><div id="Transcription_factors_and_intracellular_receptors178" style="font-size:114%;margin:0 4em"><a href="Transcription_factor" title="Transcription factor">Transcription factors</a> and <a href="Intracellular_receptor" title="Intracellular receptor">intracellular receptors</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(1)_Basic_domains178" style="font-size:114%;margin:0 4em"><i>(1) Basic domains</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.1) Basic</i> <a href="Leucine_zipper" title="Leucine zipper">leucine zipper</a> (<a href="BZIP_domain" title="BZIP domain">bZIP</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><a href="Activating_transcription_factor" title="Activating transcription factor">Activating transcription factor</a>
<ul><li><a href="Apoptosis-antagonizing_transcription_factor" class="mw-redirect" title="Apoptosis-antagonizing transcription factor">AATF</a></li>
<li><a href="ATF1" title="ATF1">1</a></li>
<li><a href="Activating_transcription_factor_2" title="Activating transcription factor 2">2</a></li>
<li><a href="ATF3" title="ATF3">3</a></li>
<li><a href="ATF4" title="ATF4">4</a></li>
<li><a href="ATF5" title="ATF5">5</a></li>
<li><a href="ATF6" title="ATF6">6</a></li>
<li><a href="ATF7" title="ATF7">7</a></li></ul></li>
<li><a href="AP-1_transcription_factor" title="AP-1 transcription factor">AP-1</a>
<ul><li><a href="C-Fos" class="mw-redirect" title="C-Fos">c-Fos</a></li>
<li><a href="FOSB" title="FOSB">FOSB</a></li>
<li><a href="FOSL1" title="FOSL1">FOSL1</a></li>
<li><a href="FOSL2" title="FOSL2">FOSL2</a></li>
<li><a href="Jun_dimerization_protein" title="Jun dimerization protein">JDP2</a></li>
<li><a href="C-jun" class="mw-redirect" title="C-jun">c-Jun</a></li>
<li><a href="JUNB" title="JUNB">JUNB</a></li>
<li><a href="JunD" title="JunD">JunD</a></li></ul></li>
<li><i>BACH</i>
<ul><li><a href="BACH1" title="BACH1">1</a></li>
<li><a href="BACH2" title="BACH2">2</a></li></ul></li>
<li><a href="BATF_(gene)" title="BATF (gene)">BATF</a></li>
<li><a href="BLZF1" class="mw-redirect" title="BLZF1">BLZF1</a></li>
<li><a href="Ccaat-enhancer-binding_proteins" class="mw-redirect" title="Ccaat-enhancer-binding proteins">C/EBP</a>
<ul><li><a href="CEBPA" title="CEBPA">α</a></li>
<li><a href="CEBPB" title="CEBPB">β</a></li>
<li><a href="CEBPG" title="CEBPG">γ</a></li>
<li><a href="CEBPD" title="CEBPD">δ</a></li>
<li><a href="CEBPE" title="CEBPE">ε</a></li>
<li><a href="CCAAT/enhancer_binding_protein_zeta" title="CCAAT/enhancer binding protein zeta">ζ</a></li></ul></li>
<li><a href="CREB" title="CREB">CREB</a>
<ul><li><a href="CREB1" title="CREB1">1</a></li>
<li><a href="CREB3" title="CREB3">3</a></li>
<li><a href="CREBL1" title="CREBL1">L1</a></li></ul></li>
<li><a href="CAMP_responsive_element_modulator" title="CAMP responsive element modulator">CREM</a></li>
<li><a href="DBP_(gene)" title="DBP (gene)">DBP</a></li>
<li><a href="DNA_damage-inducible_transcript_3" title="DNA damage-inducible transcript 3">DDIT3</a></li>
<li><a href="GABPA" title="GABPA">GABPA</a></li>
<li><a href="Gcn4" title="Gcn4">GCN4</a></li>
<li><a href="HLF_(gene)" title="HLF (gene)">HLF</a></li>
<li><a href="MAF_(gene)" title="MAF (gene)">MAF</a>
<ul><li><a href="MAFB_(gene)" title="MAFB (gene)">B</a></li>
<li><a href="Small_Maf" title="Small Maf">sMaf</a>
<ul><li><a href="MAFF_(gene)" title="MAFF (gene)">F</a></li>
<li><a href="MAFG" title="MAFG">G</a></li>
<li><a href="MAFK" title="MAFK">K</a></li></ul></li></ul></li>
<li><i>NFE</i>
<ul><li><a href="NFE2" title="NFE2">2</a></li>
<li><a href="NFE2L1" title="NFE2L1">L1</a></li>
<li><a href="NFE2L2" title="NFE2L2">L2</a></li>
<li><a href="NFE2L3" title="NFE2L3">L3</a></li></ul></li>
<li><a href="NFIL3" title="NFIL3">NFIL3</a></li>
<li><a href="NRL_(gene)" title="NRL (gene)">NRL</a></li>
<li><i>NRF</i>
<ul><li><a href="NRF1" title="NRF1">1</a></li>
<li><a href="NFE2L2" title="NFE2L2">2</a></li>
<li><a href="NFE2L3" title="NFE2L3">3</a></li></ul></li>
<li><a href="XBP1" title="XBP1">XBP1</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.2) Basic helix-loop-helix</i> (<a href="Basic_helix-loop-helix" class="mw-redirect" title="Basic helix-loop-helix">bHLH</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group A</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Achaete-scute_complex" title="Achaete-scute complex">AS-C</a>
<ul><li><a href="ASCL1" title="ASCL1">ASCL1</a></li>
<li><a href="ASCL2" title="ASCL2">ASCL2</a></li></ul></li>
<li><a href="ATOH1" title="ATOH1">ATOH1</a></li>
<li><i>HAND</i>
<ul><li><a href="HAND1" title="HAND1">1</a></li>
<li><a href="HAND2" title="HAND2">2</a></li></ul></li>
<li><a href="MESP2" title="MESP2">MESP2</a></li>
<li><a href="Myogenic_regulatory_factors" title="Myogenic regulatory factors">Myogenic regulatory factors</a>
<ul><li><a href="MyoD" title="MyoD">MyoD</a></li>
<li><a href="Myogenin" title="Myogenin">Myogenin</a></li>
<li><a href="MYF5" title="MYF5">MYF5</a></li>
<li><a href="MYF6" title="MYF6">MYF6</a></li></ul></li>
<li><a href="NeuroD" title="NeuroD">NeuroD</a>
<ul><li><a href="NEUROD1" title="NEUROD1">1</a></li>
<li><a href="NEUROD2" title="NEUROD2">2</a></li></ul></li>
<li><a href="Neurogenins" title="Neurogenins">Neurogenins</a>
<ul><li><a href="NEUROG1" class="mw-redirect" title="NEUROG1">1</a></li>
<li><a href="NEUROG2" class="mw-redirect" title="NEUROG2">2</a></li>
<li><a href="NEUROG3" class="mw-redirect" title="NEUROG3">3</a></li></ul></li>
<li><i>OLIG</i>
<ul><li><a href="OLIG1" title="OLIG1">1</a></li>
<li><a href="OLIG2" title="OLIG2">2</a></li></ul></li>
<li><i>Paraxis</i>
<ul><li><a href="TCF15" class="mw-redirect" title="TCF15">TCF15</a></li>
<li><a href="Scleraxis" title="Scleraxis">Scleraxis</a></li></ul></li>
<li><i>SLC</i>
<ul><li><a href="LYL1" title="LYL1">LYL1</a></li>
<li><i>TAL</i>
<ul><li><a href="TAL1" title="TAL1">1</a></li>
<li><a href="TAL2" title="TAL2">2</a></li></ul></li></ul></li>
<li><a href="Twist_transcription_factor" class="mw-redirect" title="Twist transcription factor">Twist</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group B</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="FIGLA" title="FIGLA">FIGLA</a></li>
<li><a href="Myc" title="Myc">Myc</a>
<ul><li><a href="MYC" title="MYC">c-Myc</a></li>
<li><a href="MYCL" title="MYCL">l-Myc</a></li>
<li><a href="N-Myc" title="N-Myc">n-Myc</a></li></ul></li>
<li><a href="MXD4" title="MXD4">MXD4</a></li>
<li><a href="TCF4" title="TCF4">TCF4</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group C<br>bHLH-<a href="PAS_domain" title="PAS domain">PAS</a></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Aryl_hydrocarbon_receptor" title="Aryl hydrocarbon receptor">AhR</a></li>
<li><a href="Aryl_hydrocarbon_receptor_repressor" title="Aryl hydrocarbon receptor repressor">AHRR</a></li>
<li><a href="Aryl_hydrocarbon_receptor_nuclear_translocator" title="Aryl hydrocarbon receptor nuclear translocator">ARNT</a>
<ul><li><a href="ARNTL" class="mw-redirect" title="ARNTL">ARNTL</a></li>
<li><a href="ARNTL2" title="ARNTL2">ARNTL2</a></li></ul></li>
<li><a href="CLOCK" title="CLOCK">CLOCK</a></li>
<li><a href="Hypoxia-inducible_factor" title="Hypoxia-inducible factor">HIF</a>
<ul><li><a href="HIF1A" title="HIF1A">1A</a></li>
<li><a href="EPAS1" title="EPAS1">EPAS1</a></li>
<li><a href="HIF3A" title="HIF3A">3A</a></li></ul></li>
<li>NPAS
<ul><li><a href="NPAS1" title="NPAS1">1</a></li>
<li><a href="NPAS2" title="NPAS2">2</a></li>
<li><a href="NPAS3" title="NPAS3">3</a></li></ul></li>
<li><i>PER</i>
<ul><li><a href="PER1" class="mw-redirect" title="PER1">1</a></li>
<li><a href="PER2" title="PER2">2</a></li>
<li><a href="PER3" title="PER3">3</a></li>
<li><a href="Period_(gene)" title="Period (gene)">Period</a></li></ul></li>
<li><i>SIM</i>
<ul><li><a href="SIM1" title="SIM1">1</a></li>
<li><a href="SIM2" title="SIM2">2</a></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group D</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>BHLH</i>
<ul><li><a href="BHLHB2" title="BHLHB2">2</a></li>
<li><a href="BHLHB3" class="mw-redirect" title="BHLHB3">3</a></li>
<li><a href="BHLHA9" title="BHLHA9">9</a></li></ul></li>
<li><a href="Pho4" title="Pho4">Pho4</a></li>
<li><i>ID</i>
<ul><li><a href="ID1" title="ID1">1</a></li>
<li><a href="ID2" title="ID2">2</a></li>
<li><a href="ID3_(gene)" title="ID3 (gene)">3</a></li>
<li><a href="ID4" title="ID4">4</a></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group E</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><i>HES</i>
<ul><li><a href="HES1" title="HES1">1</a></li>
<li><a href="Hes_family_bhlh_transcription_factor_2" title="Hes family bhlh transcription factor 2">2</a></li>
<li><a href="HES3" title="HES3">3</a></li>
<li><a href="HES4" title="HES4">4</a></li>
<li><a href="HES5" title="HES5">5</a></li>
<li><a href="HES6" title="HES6">6</a></li>
<li><a href="HES7_gene" title="HES7 gene">7</a></li></ul></li>
<li><i>HEY</i>
<ul><li><a href="HEY1" title="HEY1">1</a></li>
<li><a href="HEY2" title="HEY2">2</a></li>
<li><a href="HEYL" title="HEYL">L</a></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group F<br>bHLH-COE</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="EBF1" title="EBF1">EBF1</a></li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.3)</i> <a href="Basic_helix-loop-helix_leucine_zipper_transcription_factors" title="Basic helix-loop-helix leucine zipper transcription factors">bHLH-ZIP</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><a href="TFAP4" title="TFAP4">AP-4</a></li>
<li><a href="MAX_(gene)" title="MAX (gene)">MAX</a>
<ul><li><a href="MXD1" title="MXD1">MXD1</a></li>
<li><a href="MXD3" title="MXD3">MXD3</a></li></ul></li>
<li><a href="Microphthalmia-associated_transcription_factor" title="Microphthalmia-associated transcription factor">MITF</a></li>
<li><a href="MNT_(gene)" title="MNT (gene)">MNT</a></li>
<li><a href="MLX_(gene)" title="MLX (gene)">MLX</a></li>
<li><a href="Carbohydrate-responsive_element-binding_protein" title="Carbohydrate-responsive element-binding protein">MLXIPL</a></li>
<li><a href="MXI1" title="MXI1">MXI1</a></li>
<li><a href="Myc" title="Myc">Myc</a></li>
<li><a href="Sterol_regulatory_element-binding_protein" title="Sterol regulatory element-binding protein">SREBP</a>
<ul><li><a href="SREBF1" class="mw-redirect" title="SREBF1">1</a></li>
<li><a href="SREBF2" class="mw-redirect" title="SREBF2">2</a></li></ul></li>
<li><a href="USF1" title="USF1">USF1</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.4) NF-1</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Nuclear_factor_I" title="Nuclear factor I">NFI</a>
<ul><li><a href="NFIA" title="NFIA">A</a></li>
<li><a href="NFIB_(gene)" title="NFIB (gene)">B</a></li>
<li><a href="NFIC_(gene)" title="NFIC (gene)">C</a></li>
<li><a href="NFIX" title="NFIX">X</a></li></ul></li>
<li><a href="SMAD_(protein)" title="SMAD (protein)">SMAD</a>
<ul><li><a href="R-SMAD" title="R-SMAD">R-SMAD</a>
<ul><li><a href="Mothers_against_decapentaplegic_homolog_1" title="Mothers against decapentaplegic homolog 1">1</a></li>
<li><a href="Mothers_against_decapentaplegic_homolog_2" title="Mothers against decapentaplegic homolog 2">2</a></li>
<li><a href="Mothers_against_decapentaplegic_homolog_3" title="Mothers against decapentaplegic homolog 3">3</a></li>
<li><a href="Mothers_against_decapentaplegic_homolog_5" title="Mothers against decapentaplegic homolog 5">5</a></li>
<li><a href="Mothers_against_decapentaplegic_homolog_9" title="Mothers against decapentaplegic homolog 9">9</a></li></ul></li>
<li><a href="I-SMAD" title="I-SMAD">I-SMAD</a>
<ul><li><a href="Mothers_against_decapentaplegic_homolog_6" title="Mothers against decapentaplegic homolog 6">6</a></li>
<li><a href="Mothers_against_decapentaplegic_homolog_7" title="Mothers against decapentaplegic homolog 7">7</a></li></ul></li>
<li><a href="Mothers_against_decapentaplegic_homolog_4" title="Mothers against decapentaplegic homolog 4">4</a>)</li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.5) RF-X</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><i>RFX</i>
<ul><li><a href="RFX1" title="RFX1">1</a></li>
<li><a href="RFX2" title="RFX2">2</a></li>
<li><a href="RFX3" title="RFX3">3</a></li>
<li><a href="RFX4" title="RFX4">4</a></li>
<li><a href="RFX5" title="RFX5">5</a></li>
<li><a href="RFX6" title="RFX6">6</a></li>
<li><a href="RFXANK" title="RFXANK">ANK</a></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.6) Basic helix-span-helix (bHSH)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Activating_protein_2" title="Activating protein 2">AP-2</a>
<ul><li><a href="TFAP2A" title="TFAP2A">α</a></li>
<li><a href="TFAP2B" title="TFAP2B">β</a></li>
<li><a href="TFAP2C" title="TFAP2C">γ</a></li>
<li><a href="TFAP2D" title="TFAP2D">δ</a></li>
<li><a href="TFAP2E" title="TFAP2E">ε</a></li></ul></li></ul>
</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(2)_Zinc_finger_DNA-binding_domains178" style="font-size:114%;margin:0 4em"><i>(2)</i> <a href="Zinc_finger" title="Zinc finger">Zinc finger</a> DNA-binding domains</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.1)</i> <a href="Nuclear_receptor" title="Nuclear receptor">Nuclear receptor</a> <i>(Cys<sub>4</sub>)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 1</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Thyroid_hormone_receptor" title="Thyroid hormone receptor">Thyroid hormone</a>
<ul><li><a href="Thyroid_hormone_receptor_alpha" title="Thyroid hormone receptor alpha">α</a></li>
<li><a href="Thyroid_hormone_receptor_beta" title="Thyroid hormone receptor beta">β</a></li></ul></li>
<li><a href="Constitutive_androstane_receptor" title="Constitutive androstane receptor">CAR</a></li>
<li><a href="Farnesoid_X_receptor" title="Farnesoid X receptor">FXR</a></li>
<li><a href="Liver_X_receptor" title="Liver X receptor">LXR</a>
<ul><li><a href="Liver_X_receptor_alpha" title="Liver X receptor alpha">α</a></li>
<li><a href="Liver_X_receptor_beta" title="Liver X receptor beta">β</a></li></ul></li>
<li><a href="Peroxisome_proliferator-activated_receptor" title="Peroxisome proliferator-activated receptor">PPAR</a>
<ul><li><a href="Peroxisome_proliferator-activated_receptor_alpha" title="Peroxisome proliferator-activated receptor alpha">α</a></li>
<li><a href="Peroxisome_proliferator-activated_receptor_delta" title="Peroxisome proliferator-activated receptor delta">β/δ</a></li>
<li><a href="Peroxisome_proliferator-activated_receptor_gamma" title="Peroxisome proliferator-activated receptor gamma">γ</a></li></ul></li>
<li><a href="Pregnane_X_receptor" title="Pregnane X receptor">PXR</a></li>
<li><a href="Retinoic_acid_receptor" title="Retinoic acid receptor">RAR</a>
<ul><li><a href="Retinoic_acid_receptor_alpha" title="Retinoic acid receptor alpha">α</a></li>
<li><a href="Retinoic_acid_receptor_beta" title="Retinoic acid receptor beta">β</a></li>
<li><a href="Retinoic_acid_receptor_gamma" title="Retinoic acid receptor gamma">γ</a></li></ul></li>
<li><a href="RAR-related_orphan_receptor" title="RAR-related orphan receptor">ROR</a>
<ul><li><a href="RAR-related_orphan_receptor_alpha" title="RAR-related orphan receptor alpha">α</a></li>
<li><a href="RAR-related_orphan_receptor_beta" title="RAR-related orphan receptor beta">β</a></li>
<li><a href="RAR-related_orphan_receptor_gamma" title="RAR-related orphan receptor gamma">γ</a></li></ul></li>
<li><a href="Rev-ErbA" class="mw-redirect" title="Rev-ErbA">Rev-ErbA</a>
<ul><li><a href="Rev-ErbA_alpha" title="Rev-ErbA alpha">α</a></li>
<li><a href="Rev-ErbA_beta" title="Rev-ErbA beta">β</a></li></ul></li>
<li><a href="Calcitriol_receptor" class="mw-redirect" title="Calcitriol receptor">VDR</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 2</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Chicken_ovalbumin_upstream_promoter-transcription_factor" title="Chicken ovalbumin upstream promoter-transcription factor">COUP-TF</a>
<ul><li>(<a href="COUP-TFI" title="COUP-TFI">I</a></li>
<li><a href="COUP-TFII" title="COUP-TFII">II</a></li></ul></li>
<li><a href="V-erbA-related_gene" title="V-erbA-related gene">Ear-2</a></li>
<li><a href="Hepatocyte_nuclear_factor_4" title="Hepatocyte nuclear factor 4">HNF4</a>
<ul><li><a href="Hepatocyte_nuclear_factor_4_alpha" title="Hepatocyte nuclear factor 4 alpha">α</a></li>
<li><a href="Hepatocyte_nuclear_factor_4_gamma" title="Hepatocyte nuclear factor 4 gamma">γ</a></li></ul></li>
<li><a href="Photoreceptor_cell-specific_nuclear_receptor" title="Photoreceptor cell-specific nuclear receptor">PNR</a></li>
<li><a href="Retinoid_X_receptor" title="Retinoid X receptor">RXR</a>
<ul><li><a href="Retinoid_X_receptor_alpha" title="Retinoid X receptor alpha">α</a></li>
<li><a href="Retinoid_X_receptor_beta" title="Retinoid X receptor beta">β</a></li>
<li><a href="Retinoid_X_receptor_gamma" title="Retinoid X receptor gamma">γ</a></li></ul></li>
<li><a href="Testicular_receptor" title="Testicular receptor">Testicular receptor</a>
<ul><li><a href="Testicular_receptor_2" title="Testicular receptor 2">2</a></li>
<li><a href="Testicular_receptor_4" title="Testicular receptor 4">4</a></li></ul></li>
<li><a href="TLX" title="TLX">TLX</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 3</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Steroid_hormone_receptor" title="Steroid hormone receptor">Steroid hormone</a>
<ul><li><a href="Androgen_receptor" title="Androgen receptor">Androgen</a></li>
<li><a href="Estrogen_receptor" title="Estrogen receptor">Estrogen</a>
<ul><li><a href="Estrogen_receptor_alpha" title="Estrogen receptor alpha">α</a></li>
<li><a href="Estrogen_receptor_beta" title="Estrogen receptor beta">β</a></li></ul></li>
<li><a href="Glucocorticoid_receptor" title="Glucocorticoid receptor">Glucocorticoid</a></li>
<li><a href="Mineralocorticoid_receptor" title="Mineralocorticoid receptor">Mineralocorticoid</a></li>
<li><a href="Progesterone_receptor" title="Progesterone receptor">Progesterone</a></li></ul></li>
<li><a href="Estrogen-related_receptor" title="Estrogen-related receptor">Estrogen related</a>
<ul><li><a href="Estrogen-related_receptor_alpha" title="Estrogen-related receptor alpha">α</a></li>
<li><a href="Estrogen-related_receptor_beta" title="Estrogen-related receptor beta">β</a></li>
<li><a href="Estrogen-related_receptor_gamma" title="Estrogen-related receptor gamma">γ</a></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 4</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Nur_(biology)" class="mw-redirect" title="Nur (biology)">NUR</a>
<ul><li><a href="Nuclear_receptor_4A1" title="Nuclear receptor 4A1">NGFIB</a></li>
<li><a href="Nuclear_receptor_4A3" title="Nuclear receptor 4A3">NOR1</a></li>
<li><a href="Nuclear_receptor_4A2" title="Nuclear receptor 4A2">NURR1</a></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 5</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Liver_receptor_homolog-1" title="Liver receptor homolog-1">LRH-1</a></li>
<li><a href="Steroidogenic_factor_1" title="Steroidogenic factor 1">SF1</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 6</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Germ_cell_nuclear_factor" title="Germ cell nuclear factor">GCNF</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 0</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="DAX1" title="DAX1">DAX1</a></li>
<li><a href="Small_heterodimer_partner" title="Small heterodimer partner">SHP</a></li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.2) Other Cys<sub>4</sub></i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">
<ul><li><a href="GATA_transcription_factor" title="GATA transcription factor">GATA</a>
<ul><li><a href="GATA1" title="GATA1">1</a></li>
<li><a href="GATA2" title="GATA2">2</a></li>
<li><a href="GATA3" title="GATA3">3</a></li>
<li><a href="GATA4" title="GATA4">4</a></li>
<li><a href="GATA5" title="GATA5">5</a></li>
<li><a href="GATA6" title="GATA6">6</a></li></ul></li>
<li><i>MTA</i>
<ul><li><a href="MTA1" title="MTA1">1</a></li>
<li><a href="MTA2" title="MTA2">2</a></li>
<li><a href="MTA3" title="MTA3">3</a></li></ul></li>
<li><a href="Tricho-rhino-phalangeal_syndrome_Type_1" title="Tricho-rhino-phalangeal syndrome Type 1">TRPS1</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.3) Cys<sub>2</sub>His<sub>2</sub></i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><a href="General_transcription_factor" title="General transcription factor">General transcription factors</a>
<ul><li><a href="Transcription_factor_II_A" title="Transcription factor II A">TFIIA</a></li>
<li><a href="Transcription_factor_II_B" title="Transcription factor II B">TFIIB</a></li>
<li><a href="Transcription_factor_II_D" title="Transcription factor II D">TFIID</a></li>
<li><a href="Transcription_factor_II_E" title="Transcription factor II E">TFIIE</a>
<ul><li><a href="GTF2E1" title="GTF2E1">1</a></li>
<li><a href="GTF2E2" title="GTF2E2">2</a></li></ul></li>
<li><a href="Transcription_factor_II_F" title="Transcription factor II F">TFIIF</a></li>
<li><a href="GTF2F1" title="GTF2F1">1</a></li>
<li><a href="GTF2F2" title="GTF2F2">2</a>
<ul><li><a href="Transcription_factor_II_H" title="Transcription factor II H">TFIIH</a></li>
<li><a href="GTF2H1" title="GTF2H1">1</a></li>
<li><a href="GTF2H2" title="GTF2H2">2</a></li>
<li><a href="GTF2H4" title="GTF2H4">4</a></li>
<li><a href="GTF2I" title="GTF2I">2I</a></li>
<li><a href="GTF3A" title="GTF3A">3A</a></li>
<li><a href="GTF3C1" title="GTF3C1">3C1</a></li>
<li><a href="GTF3C2" title="GTF3C2">3C2</a></li></ul></li></ul></li></ul>
<ul><li><a href="ATBF1" title="ATBF1">ATBF1</a></li>
<li><i><a href="B-cell_CLL/lymphoma" title="B-cell CLL/lymphoma">BCL</a></i>
<ul><li><a href="BCL6" title="BCL6">6</a></li>
<li><a href="BCL11A" title="BCL11A">11A</a></li>
<li><a href="BCL11B" title="BCL11B">11B</a></li></ul></li>
<li><a href="CTCF" title="CTCF">CTCF</a></li>
<li><a href="E4F1" title="E4F1">E4F1</a></li>
<li><a href="Early_growth_response_proteins" title="Early growth response proteins">EGR</a>
<ul><li><a href="EGR1" title="EGR1">1</a></li>
<li><a href="EGR2" title="EGR2">2</a></li>
<li><a href="EGR3" title="EGR3">3</a></li>
<li><a href="EGR4" title="EGR4">4</a></li></ul></li>
<li><a href="ERV3" title="ERV3">ERV3</a></li>
<li><a href="GFI1" title="GFI1">GFI1</a></li>
<li><i>GLI family</i>
<ul><li><a href="GLI1" title="GLI1">1</a></li>
<li><a href="GLI2" title="GLI2">2</a></li>
<li><a href="GLI3" title="GLI3">3</a></li>
<li><a href="RE1-silencing_transcription_factor" title="RE1-silencing transcription factor">REST</a></li>
<li><a href="GLIS1" title="GLIS1">S1</a></li>
<li><a href="GLIS2" title="GLIS2">S2</a></li>
<li><a href="YY1" title="YY1">YY1</a></li></ul></li>
<li><i>HIC</i>
<ul><li><a href="HIC1" title="HIC1">1</a></li>
<li><a href="HIC2" title="HIC2">2</a></li></ul></li>
<li><i>HIVEP</i>
<ul><li><a href="HIVEP1" title="HIVEP1">1</a></li>
<li><a href="HIVEP2" title="HIVEP2">2</a></li>
<li><a href="HIVEP3" title="HIVEP3">3</a></li></ul></li>
<li><i>IKZF</i>
<ul><li><a href="IKZF1" title="IKZF1">1</a></li>
<li><a href="IKZF2" title="IKZF2">2</a></li>
<li><a href="IKZF3" title="IKZF3">3</a></li></ul></li>
<li><i>ILF</i>
<ul><li><a href="ILF2" title="ILF2">2</a></li>
<li><a href="ILF3" title="ILF3">3</a></li></ul></li>
<li><a href="Kruppel-like_factors" title="Kruppel-like factors">Sp/KLF family</a>
<ul><li><i>KLF</i>
<ul><li><a href="KLF1" title="KLF1">1</a></li>
<li><a href="KLF2" title="KLF2">2</a></li>
<li><a href="KLF3" title="KLF3">3</a></li>
<li><a href="KLF4" title="KLF4">4</a></li>
<li><a href="KLF5" title="KLF5">5</a></li>
<li><a href="KLF6" title="KLF6">6</a></li>
<li><a href="KLF7" title="KLF7">7</a></li>
<li><a href="KLF8" title="KLF8">8</a></li>
<li><a href="KLF9" title="KLF9">9</a></li>
<li><a href="KLF10" title="KLF10">10</a></li>
<li><a href="KLF11" title="KLF11">11</a></li>
<li><a href="KLF12" title="KLF12">12</a></li>
<li><a href="KLF13" title="KLF13">13</a></li>
<li><a href="KLF14" title="KLF14">14</a></li>
<li><a href="KLF15" title="KLF15">15</a></li>
<li><a href="KLF17" title="KLF17">17</a></li></ul></li>
<li><i>SP</i>
<ul><li><a href="Sp1_transcription_factor" class="mw-redirect" title="Sp1 transcription factor">1</a></li>
<li><a href="SP2_(gene)" class="mw-redirect" title="SP2 (gene)">2</a></li>
<li><a href="SP4_(gene)" class="mw-redirect" title="SP4 (gene)">4</a></li>
<li><a href="Sp7_transcription_factor" title="Sp7 transcription factor">7</a></li>
<li><a href="Sp8_transcription_factor" title="Sp8 transcription factor">8</a></li></ul></li></ul></li>
<li><a href="MTF1" title="MTF1">MTF1</a></li>
<li><a href="MYT1" title="MYT1">MYT1</a></li>
<li><a href="OSR1" title="OSR1">OSR1</a></li>
<li><a href="PRDM9" title="PRDM9">PRDM9</a></li>
<li><i>SALL</i>
<ul><li><a href="SALL1" title="SALL1">1</a></li>
<li><a href="SALL2" title="SALL2">2</a></li>
<li><a href="SALL3" title="SALL3">3</a></li>
<li><a href="SALL4" title="SALL4">4</a></li></ul></li>
<li><a href="TSHZ3" title="TSHZ3">TSHZ3</a></li>
<li><a href="WT1" class="mw-redirect" title="WT1">WT1</a></li>
<li><a href="Zbtb7" title="Zbtb7">Zbtb7</a>
<ul><li><a href="ZBTB7A" title="ZBTB7A">7A</a></li>
<li><a href="ZBTB7B" title="ZBTB7B">7B</a></li></ul></li>
<li><i>ZBTB</i>
<ul><li><a href="ZBTB11" title="ZBTB11">11</a></li>
<li><a href="Zinc_finger_and_BTB_domain-containing_protein_16" title="Zinc finger and BTB domain-containing protein 16">16</a></li>
<li><a href="ZBTB17" title="ZBTB17">17</a></li>
<li><a href="ZBTB20" title="ZBTB20">20</a></li>
<li><a href="ZBTB21" title="ZBTB21">21</a></li>
<li><a href="ZBTB32" title="ZBTB32">32</a></li>
<li><a href="ZBTB33" title="ZBTB33">33</a></li>
<li><a href="ZBTB40" title="ZBTB40">40</a></li></ul></li>
<li><i>zinc finger</i>
<ul><li><a href="ZNF3" title="ZNF3">3</a></li>
<li><a href="ZNF7" title="ZNF7">7</a></li>
<li><a href="CNBP" title="CNBP">9</a></li>
<li><a href="ZNF10" title="ZNF10">10</a></li>
<li><a href="ZNF19" title="ZNF19">19</a></li>
<li><a href="ZNF22" title="ZNF22">22</a></li>
<li><a href="ZNF24" title="ZNF24">24</a></li>
<li><a href="ZNF33B" title="ZNF33B">33B</a></li>
<li><a href="ZNF34" title="ZNF34">34</a></li>
<li><a href="ZNF35" title="ZNF35">35</a></li>
<li><a href="ZNF41" title="ZNF41">41</a></li>
<li><a href="ZNF43" title="ZNF43">43</a></li>
<li><a href="ZNF44" title="ZNF44">44</a></li>
<li><a href="BCL6" title="BCL6">51</a></li>
<li><a href="ZNF74" title="ZNF74">74</a></li>
<li><a href="ZNF143" title="ZNF143">143</a></li>
<li><a href="ZNF146" title="ZNF146">146</a></li>
<li><a href="ZNF148" title="ZNF148">148</a></li>
<li><a href="Zinc_finger_protein_165" title="Zinc finger protein 165">165</a></li>
<li><a href="ZNF202" title="ZNF202">202</a></li>
<li><a href="ZNF217" title="ZNF217">217</a></li>
<li><a href="ZNF219" title="ZNF219">219</a></li>
<li><a href="ZNF238" title="ZNF238">238</a></li>
<li><a href="ZNF239" title="ZNF239">239</a></li>
<li><a href="ZNF259" title="ZNF259">259</a></li>
<li><a href="ZNF267" title="ZNF267">267</a></li>
<li><a href="EGR1" title="EGR1">268</a></li>
<li><a href="ZNF281" title="ZNF281">281</a></li>
<li><a href="ZNF300" title="ZNF300">300</a></li>
<li><a href="ZNF318" title="ZNF318">318</a></li>
<li><a href="ZNF330" title="ZNF330">330</a></li>
<li><a href="ZNF346" title="ZNF346">346</a></li>
<li><a href="ZNF350" title="ZNF350">350</a></li>
<li><a href="ZNF365" title="ZNF365">365</a></li>
<li><a href="ZNF366" title="ZNF366">366</a></li>
<li><a href="ZNF384" title="ZNF384">384</a></li>
<li><a href="ZNF423" title="ZNF423">423</a></li>
<li><a href="ZNF451" title="ZNF451">451</a></li>
<li><a href="ZNF452" title="ZNF452">452</a></li>
<li><a href="ZNF471" title="ZNF471">471</a></li>
<li><a href="ZNF593" title="ZNF593">593</a></li>
<li><a href="ZNF638" title="ZNF638">638</a></li>
<li><a href="ZNF644" title="ZNF644">644</a></li>
<li><a href="ZNF649" title="ZNF649">649</a></li>
<li><a href="ZNF655" title="ZNF655">655</a></li>
<li><a href="ZNF804A" class="mw-redirect" title="ZNF804A">804A</a></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.4) Cys<sub>6</sub></i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">
<ul><li><a href="HIVEP1" title="HIVEP1">HIVEP1</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.5) Alternating composition</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><a href="Autoimmune_regulator" title="Autoimmune regulator">AIRE</a></li>
<li><a href="DIDO1" title="DIDO1">DIDO1</a></li>
<li><a href="GRLF1" title="GRLF1">GRLF1</a></li>
<li><i>ING</i>
<ul><li><a href="ING1" title="ING1">1</a></li>
<li><a href="ING2" title="ING2">2</a></li>
<li><a href="ING4" title="ING4">4</a></li></ul></li>
<li><i>JARID</i>
<ul><li><a href="KDM5A" title="KDM5A">1A</a></li>
<li><a href="KDM5B" class="mw-redirect" title="KDM5B">1B</a></li>
<li><a href="KDM5C" title="KDM5C">1C</a></li>
<li><a href="KDM5D" title="KDM5D">1D</a></li>
<li><a href="JARID2" title="JARID2">2</a></li></ul></li>
<li><a href="KDM3B" title="KDM3B">JMJD1B</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.6) WRKY</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">
<ul><li><a href="WRKY_protein_domain" title="WRKY protein domain">WRKY</a></li></ul>
</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(3)_Helix-turn-helix_domains178" style="font-size:114%;margin:0 4em"><i>(3)</i> <a href="Helix-turn-helix" title="Helix-turn-helix">Helix-turn-helix</a> <i>domains</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.1)</i> <a href="Homeodomain_fold" class="mw-redirect" title="Homeodomain fold">Homeodomain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i><a href="Antennapedia" title="Antennapedia">Antennapedia</a></i></span><br><span class="nobold"><i>ANTP class</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>protoHOX</i></span><br><span class="nobold"><i>Hox-like</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="ParaHox" title="ParaHox">ParaHox</a>
<ul><li><a href="Gsx_(gene_family)" title="Gsx (gene family)">Gsx</a>
<ul><li><a href="GSX1" title="GSX1">1</a></li>
<li><a href="GSX2" title="GSX2">2</a></li></ul></li>
<li><a href="Xlox" class="mw-redirect" title="Xlox">Xlox</a>
<ul><li><a href="PDX1" title="PDX1">PDX1</a></li></ul></li>
<li><a href="Cdx" title="Cdx">Cdx</a>
<ul><li><a href="CDX1" class="mw-redirect" title="CDX1">1</a></li>
<li><a href="CDX2" class="mw-redirect" title="CDX2">2</a></li>
<li><a href="CDX4_(gene)" class="mw-redirect" title="CDX4 (gene)">4</a></li></ul></li></ul></li>
<li>extended Hox: <a href="Evx1" title="Evx1">Evx1</a></li>
<li>Evx2</li>
<li><a href="MEOX1" title="MEOX1">MEOX1</a></li>
<li><a href="MEOX2" title="MEOX2">MEOX2</a></li>
<li><a href="Homeobox" title="Homeobox">Homeobox</a>
<ul><li><a href="Homeobox_A1" title="Homeobox A1">A1</a></li>
<li><a href="HOXA2" title="HOXA2">A2</a></li>
<li><a href="HOXA3" title="HOXA3">A3</a></li>
<li><a href="HOXA4" title="HOXA4">A4</a></li>
<li><a href="HOXA5" title="HOXA5">A5</a></li>
<li><a href="HOXA7" title="HOXA7">A7</a></li>
<li><a href="HOXA9" title="HOXA9">A9</a></li>
<li><a href="Homeobox_A10" title="Homeobox A10">A10</a></li>
<li><a href="HOXA11" title="HOXA11">A11</a></li>
<li><a href="HOXA13" title="HOXA13">A13</a></li>
<li><a href="HOXB1" title="HOXB1">B1</a></li>
<li><a href="HOXB2" title="HOXB2">B2</a></li>
<li><a href="HOXB3" title="HOXB3">B3</a></li>
<li><a href="HOXB4" title="HOXB4">B4</a></li>
<li><a href="HOXB5" title="HOXB5">B5</a></li>
<li><a href="HOXB6" title="HOXB6">B6</a></li>
<li><a href="HOXB7" title="HOXB7">B7</a></li>
<li><a href="HOXB8" title="HOXB8">B8</a></li>
<li><a href="HOXB9" title="HOXB9">B9</a></li>
<li><a href="HOXB13" title="HOXB13">B13</a></li>
<li><a href="HOXC4" title="HOXC4">C4</a></li>
<li><a href="HOXC5" title="HOXC5">C5</a></li>
<li><a href="HOXC6" title="HOXC6">C6</a></li>
<li><a href="HOXC8" title="HOXC8">C8</a></li>
<li><a href="HOXC9" title="HOXC9">C9</a></li>
<li><a href="HOXC10" title="HOXC10">C10</a></li>
<li><a href="HOXC11" title="HOXC11">C11</a></li>
<li><a href="HOXC12" title="HOXC12">C12</a></li>
<li><a href="HOXC13" title="HOXC13">C13</a></li>
<li><a href="HOXD1" title="HOXD1">D1</a></li>
<li><a href="HOXD3" title="HOXD3">D3</a></li>
<li><a href="HOXD4" title="HOXD4">D4</a></li>
<li><a href="HOXD8" title="HOXD8">D8</a></li>
<li><a href="HOXD9" title="HOXD9">D9</a></li>
<li><a href="HOXD10" title="HOXD10">D10</a></li>
<li><a href="HOXD11" title="HOXD11">D11</a></li>
<li><a href="HOXD12" title="HOXD12">D12</a></li>
<li><a href="HOXD13" title="HOXD13">D13</a></li></ul></li>
<li>GBX1</li>
<li><a href="GBX2" title="GBX2">GBX2</a></li>
<li><a href="MNX1" title="MNX1">MNX1</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>metaHOX</i></span><br><span class="nobold"><i>NK-like</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li>BARHL1</li>
<li><a href="BARHL2" title="BARHL2">BARHL2</a></li>
<li>BARX1</li>
<li>BARX2</li>
<li><a href="Brain-specific_homeobox" title="Brain-specific homeobox">BSX</a></li>
<li><i>DBX</i>
<ul><li><a href="DBX1" title="DBX1">1</a></li>
<li><a href="DBX2" title="DBX2">2</a></li></ul></li>
<li><a href="DLX_gene_family" title="DLX gene family">DLX</a>
<ul><li><a href="DLX1" title="DLX1">1</a></li>
<li><a href="DLX2" title="DLX2">2</a></li>
<li><a href="DLX3_(gene)" class="mw-redirect" title="DLX3 (gene)">3</a></li>
<li><a href="DLX4" title="DLX4">4</a></li>
<li><a href="DLX5" title="DLX5">5</a></li>
<li><a href="DLX6" title="DLX6">6</a></li></ul></li>
<li><i><a href="EMX_homeogene" title="EMX homeogene">EMX</a></i>
<ul><li><a href="EMX1" title="EMX1">1</a></li>
<li><a href="EMX2" title="EMX2">2</a></li></ul></li>
<li><i>EN</i>
<ul><li><a href="EN1_(gene)" title="EN1 (gene)">1</a></li>
<li><a href="EN2_(gene)" title="EN2 (gene)">2</a></li></ul></li>
<li><a href="HHEX" title="HHEX">HHEX</a></li>
<li><a href="HLX_(gene)" title="HLX (gene)">HLX</a></li>
<li><a href="LBX1" title="LBX1">LBX1</a></li>
<li><a href="LBX2" title="LBX2">LBX2</a></li>
<li><i>MSX</i>
<ul><li><a href="MSX1" class="mw-redirect" title="MSX1">1</a></li>
<li><a href="Msh_homeobox_2" title="Msh homeobox 2">2</a></li></ul></li>
<li><a href="Homeobox_protein_NANOG" title="Homeobox protein NANOG">NANOG</a></li>
<li><a href="NKX-homeodomain_factor" title="NKX-homeodomain factor">NKX</a>
<ul><li><a href="NK2_homeobox_1" title="NK2 homeobox 1">2-1</a></li>
<li><a href="NKX2-2" title="NKX2-2">2-2</a></li>
<li><a href="NKX2-3" title="NKX2-3">2-3</a></li>
<li><a href="Homeobox_protein_Nkx-2.5" title="Homeobox protein Nkx-2.5">2-5</a></li>
<li><a href="NKX3-1" title="NKX3-1">3-1</a></li>
<li><a href="NKX3-2" title="NKX3-2">3-2</a></li>
<li>HMX1</li>
<li>HMX2</li>
<li>HMX3</li>
<li><a href="NKX6-1" title="NKX6-1">6-1</a></li>
<li><a href="NKX6-2" title="NKX6-2">6-2</a></li></ul></li>
<li><a href="Notochord_homeobox_(NOTO)_gene" title="Notochord homeobox (NOTO) gene">NOTO</a></li>
<li><a href="TLX1" title="TLX1">TLX1</a></li>
<li><a href="TLX2" title="TLX2">TLX2</a></li>
<li><a href="TLX3" title="TLX3">TLX3</a></li>
<li><a href="VAX1" title="VAX1">VAX1</a></li>
<li>VAX2</li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">other</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Aristaless_related_homeobox" title="Aristaless related homeobox">ARX</a></li>
<li><a href="CRX_(gene)" title="CRX (gene)">CRX</a></li>
<li><a href="CUTL1" title="CUTL1">CUTL1</a></li>
<li><i>FHL</i>
<ul><li><a href="FHL1" title="FHL1">1</a></li>
<li><a href="FHL2" title="FHL2">2</a></li>
<li><a href="FHL3" title="FHL3">3</a></li></ul></li>
<li><a href="HESX1" title="HESX1">HESX1</a></li>
<li><a href="HOPX" title="HOPX">HOPX</a></li>
<li><i>LMX</i>
<ul><li><a href="LMX1A" title="LMX1A">1A</a></li>
<li><a href="LMX1B" title="LMX1B">1B</a></li></ul></li>
<li><a href="NOBOX" title="NOBOX">NOBOX</a></li>
<li>TALE
<ul><li><a href="Iroquois_homeobox_factor" title="Iroquois homeobox factor">IRX</a>
<ul><li><a href="IRX1" title="IRX1">1</a></li>
<li><a href="IRX2" title="IRX2">2</a></li>
<li><a href="IRX3" title="IRX3">3</a></li>
<li><a href="IRX4" title="IRX4">4</a></li>
<li><a href="IRX5" title="IRX5">5</a></li>
<li><a href="IRX6" title="IRX6">6</a></li>
<li><a href="MKX" title="MKX">MKX</a></li></ul></li>
<li><i>MEIS</i>
<ul><li><a href="MEIS1" title="MEIS1">1</a></li>
<li><a href="MEIS2" title="MEIS2">2</a></li></ul></li>
<li><i>PBX</i>
<ul><li><a href="PBX1" title="PBX1">1</a></li>
<li><a href="PBX2" title="PBX2">2</a></li>
<li><a href="PBX3" title="PBX3">3</a></li></ul></li>
<li><i>PKNOX</i>
<ul><li><a href="PKNOX1" title="PKNOX1">1</a></li>
<li><a href="PKNOX2" title="PKNOX2">2</a></li></ul></li>
<li><i>SIX</i>
<ul><li><a href="SIX1" class="mw-redirect" title="SIX1">1</a></li>
<li><a href="SIX2" title="SIX2">2</a></li>
<li><a href="SIX3" title="SIX3">3</a></li>
<li><a href="SIX4" title="SIX4">4</a></li>
<li><a href="SIX5" title="SIX5">5</a></li></ul></li></ul></li>
<li><i>PHF</i>
<ul><li><a href="PHF1" title="PHF1">1</a></li>
<li><a href="PHF3" title="PHF3">3</a></li>
<li><a href="PHF6" title="PHF6">6</a></li>
<li><a href="PHF8" title="PHF8">8</a></li>
<li><a href="PHF10" title="PHF10">10</a></li>
<li><a href="PHF16" title="PHF16">16</a></li>
<li><a href="PHF17" class="mw-redirect" title="PHF17">17</a></li>
<li><a href="PHF20" title="PHF20">20</a></li>
<li><a href="PHF21A" title="PHF21A">21A</a></li></ul></li>
<li><a href="POU_domain" title="POU domain">POU domain</a>
<ul><li><a href="Pituitary-specific_positive_transcription_factor_1" title="Pituitary-specific positive transcription factor 1">PIT-1</a></li>
<li><a href="BRN-3" title="BRN-3">BRN-3</a>: <a href="POU4F1" title="POU4F1">A</a></li>
<li><a href="POU4F2" title="POU4F2">B</a></li>
<li><a href="POU4F3" title="POU4F3">C</a></li>
<li><a href="Octamer_transcription_factor" title="Octamer transcription factor">Octamer transcription factor</a>: <a href="POU2F1" title="POU2F1">1</a></li>
<li><a href="Oct-2" title="Oct-2">2</a></li>
<li><a href="Oct-4" title="Oct-4">3/4</a></li>
<li><a href="POU3F1" title="POU3F1">6</a></li>
<li><a href="POU3F2" title="POU3F2">7</a></li>
<li><a href="POU3F4" title="POU3F4">11</a></li></ul></li>
<li><a href="SATB2" title="SATB2">SATB2</a></li>
<li><i>ZEB</i>
<ul><li><a href="ZEB1" title="ZEB1">1</a></li>
<li><a href="ZEB2" title="ZEB2">2</a></li></ul></li></ul>
</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.2) Paired box</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Pax_genes" title="Pax genes">PAX</a>
<ul><li><a href="PAX1" title="PAX1">1</a></li>
<li><a href="PAX2" title="PAX2">2</a></li>
<li><a href="PAX3" title="PAX3">3</a></li>
<li><a href="PAX4" title="PAX4">4</a></li>
<li><a href="PAX5" title="PAX5">5</a></li>
<li><a href="PAX6" title="PAX6">6</a></li>
<li><a href="PAX7" title="PAX7">7</a></li>
<li><a href="PAX8" title="PAX8">8</a></li>
<li><a href="PAX9" title="PAX9">9</a></li></ul></li>
<li>PRRX
<ul><li><a href="PRRX1" title="PRRX1">1</a></li>
<li><a href="PRRX2" title="PRRX2">2</a></li></ul></li>
<li><a href="PROP1" title="PROP1">PROP1</a></li>
<li><i>PHOX</i>
<ul><li><a href="PHOX2A" title="PHOX2A">2A</a></li>
<li><a href="PHOX2B" title="PHOX2B">2B</a></li></ul></li>
<li><a href="Retinal_homeobox_protein_Rx" title="Retinal homeobox protein Rx">RAX</a></li>
<li><a href="Short-stature_homeobox_gene" title="Short-stature homeobox gene">SHOX</a></li>
<li><a href="SHOX2" title="SHOX2">SHOX2</a></li>
<li><a href="VSX1" title="VSX1">VSX1</a></li>
<li><a href="VSX2" title="VSX2">VSX2</a></li>
<li><a href="Bicoid_(gene)" class="mw-redirect" title="Bicoid (gene)">Bicoid</a>
<ul><li><a href="Goosecoid_protein" class="mw-redirect" title="Goosecoid protein">GSC</a></li>
<li><a href="BICD2" title="BICD2">BICD2</a></li>
<li><i>OTX</i>
<ul><li><a href="OTX1" title="OTX1">1</a></li>
<li><a href="Orthodenticle_homeobox_2" title="Orthodenticle homeobox 2">2</a></li></ul></li>
<li><i>PITX</i>
<ul><li><a href="PITX1" title="PITX1">1</a></li>
<li><a href="PITX2" title="PITX2">2</a></li>
<li><a href="PITX3" title="PITX3">3</a></li></ul></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.3)</i> <a href="FOX_proteins" title="FOX proteins">Fork head</a> / <a href="Winged-helix_transcription_factors" title="Winged-helix transcription factors">winged helix</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><a href="E2F" title="E2F">E2F</a>
<ul><li><a href="E2F1" title="E2F1">1</a></li>
<li><a href="E2F2" title="E2F2">2</a></li>
<li><a href="E2F3" title="E2F3">3</a></li>
<li><a href="E2F4" title="E2F4">4</a></li>
<li><a href="E2F5" title="E2F5">5</a></li></ul></li>
<li><a href="FOX_proteins" title="FOX proteins">FOX proteins</a>
<ul><li><a href="FOXA1" title="FOXA1">A1</a></li>
<li><a href="FOXA2" title="FOXA2">A2</a></li>
<li><a href="FOXA3" title="FOXA3">A3</a></li>
<li><a href="FOXB1" class="mw-redirect" title="FOXB1">B1</a></li>
<li>B2</li>
<li><a href="Forkhead_box_C1" title="Forkhead box C1">C1</a></li>
<li><a href="FOXC2" title="FOXC2">C2</a></li>
<li><a href="FOXD1" class="mw-redirect" title="FOXD1">D1</a></li>
<li>D2</li>
<li><a href="FOXD3" title="FOXD3">D3</a></li>
<li><a href="FOXD4" title="FOXD4">D4</a></li>
<li>D4L1</li>
<li>D4L3</li>
<li>D4L4</li>
<li>D4L5</li>
<li>D4L6</li>
<li><a href="FOXE1" title="FOXE1">E1</a></li>
<li><a href="FOXE3" title="FOXE3">E3</a></li>
<li><a href="FOXF1" title="FOXF1">F1</a></li>
<li><a href="FOXF2" title="FOXF2">F2</a></li>
<li><a href="FOXG1" title="FOXG1">G1</a></li>
<li><a href="FOXH1" title="FOXH1">H1</a></li>
<li><a href="FOXI1" title="FOXI1">I1</a></li>
<li>I2</li>
<li><a href="FOXI3" title="FOXI3">I3</a></li>
<li><a href="FOXJ1" title="FOXJ1">J1</a></li>
<li><a href="FOXJ2" title="FOXJ2">J2</a></li>
<li>J3</li>
<li><a href="FOXK1" title="FOXK1">K1</a></li>
<li><a href="FOXK2" title="FOXK2">K2</a></li>
<li>L1</li>
<li><a href="Forkhead_box_L2" class="mw-redirect" title="Forkhead box L2">L2</a></li>
<li><a href="FOXM1" title="FOXM1">M1</a></li>
<li><a href="FOXN1" title="FOXN1">N1</a></li>
<li>N2</li>
<li><a href="FOXN3" title="FOXN3">N3</a></li>
<li>N4</li>
<li><a href="FOXO1" class="mw-redirect" title="FOXO1">O1</a></li>
<li><a href="FOXO3" title="FOXO3">O3</a></li>
<li><a href="FOXO4" title="FOXO4">O4</a></li>
<li><a href="FOXO6" title="FOXO6">O6</a></li>
<li><a href="FOXP1" title="FOXP1">P1</a></li>
<li><a href="FOXP2" title="FOXP2">P2</a></li>
<li><a href="FOXP3" title="FOXP3">P3</a></li>
<li><a href="FOXP4" title="FOXP4">P4</a></li>
<li><a href="FOXQ1" title="FOXQ1">Q1</a></li>
<li>R1</li>
<li>R2</li>
<li><a href="FOXS1" title="FOXS1">S1</a></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.4)</i> <a href="Heat_shock_factor" title="Heat shock factor">Heat shock factors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">
<ul><li><i><a href="Heat_shock_factor" title="Heat shock factor">HSF</a></i>
<ul><li><a href="HSF1" class="mw-redirect" title="HSF1">1</a></li>
<li><a href="HSF2" title="HSF2">2</a></li>
<li><a href="HSF4" title="HSF4">4</a></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.5) Tryptophan clusters</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><i>ELF</i>
<ul><li><a href="ELF2" title="ELF2">2</a></li>
<li><a href="ELF4" title="ELF4">4</a></li>
<li><a href="ELF5" title="ELF5">5</a></li></ul></li>
<li><a href="EHF_(gene)" title="EHF (gene)">EHF</a></li>
<li><i>ELK</i>
<ul><li><a href="ELK1" title="ELK1">1</a></li>
<li><a href="ELK3" title="ELK3">3</a></li>
<li><a href="ELK4" title="ELK4">4</a></li></ul></li>
<li><a href="ERF_(gene)" title="ERF (gene)">ERF</a></li>
<li><a href="ETS_transcription_factor_family" title="ETS transcription factor family">ETS</a>
<ul><li><a href="ETS1" title="ETS1">1</a></li>
<li><a href="ETS2" title="ETS2">2</a></li>
<li><a href="ERG_(gene)" title="ERG (gene)">ERG</a></li>
<li><a href="SPIB" title="SPIB">SPIB</a></li></ul></li>
<li><i>ETV</i>
<ul><li><a href="ETV1" title="ETV1">1</a></li>
<li><a href="ETV4" title="ETV4">4</a></li>
<li><a href="ERM_transcription_factor" class="mw-redirect" title="ERM transcription factor">5</a></li>
<li><a href="ETV6" title="ETV6">6</a></li></ul></li>
<li><a href="FLI1" title="FLI1">FLI1</a></li>
<li><a href="Interferon_regulatory_factors" title="Interferon regulatory factors">Interferon regulatory factors</a>
<ul><li><a href="IRF1" title="IRF1">1</a></li>
<li><a href="IRF2" title="IRF2">2</a></li>
<li><a href="IRF3" title="IRF3">3</a></li>
<li><a href="IRF4" title="IRF4">4</a></li>
<li><a href="IRF5" title="IRF5">5</a></li>
<li><a href="IRF6" title="IRF6">6</a></li>
<li><a href="IRF7" title="IRF7">7</a></li>
<li><a href="IRF8" title="IRF8">8</a></li></ul></li>
<li><a href="MYB_(gene)" title="MYB (gene)">MYB</a></li>
<li><a href="MYBL2" title="MYBL2">MYBL2</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.6) TEA domain</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">
<ul><li><i>transcriptional enhancer factor</i>
<ul><li><a href="TEAD1" title="TEAD1">1</a></li>
<li><a href="TEAD2" title="TEAD2">2</a></li>
<li><a href="TEAD3" title="TEAD3">3</a></li>
<li><a href="TEAD4" title="TEAD4">4</a></li></ul></li></ul>
</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible uncollapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(4)_β-Scaffold_factors_with_minor_groove_contacts178" style="font-size:114%;margin:0 4em">(4) <i>β-Scaffold factors with minor groove contacts</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.1)</i> <a href="Rel_homology_domain" title="Rel homology domain">Rel homology region</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><a href="NF-%CE%BAB" title="NF-κB">NF-κB</a>
<ul><li><a href="NFKB1" title="NFKB1">NFKB1</a></li>
<li><a href="NFKB2" title="NFKB2">NFKB2</a></li>
<li><a href="REL" title="REL">REL</a></li>
<li><a href="RELA" title="RELA">RELA</a></li>
<li><a href="RELB" title="RELB">RELB</a></li></ul></li>
<li><a href="NFAT" title="NFAT">NFAT</a>
<ul><li><a href="NFATC1" title="NFATC1">C1</a></li>
<li><a href="NFATC2" title="NFATC2">C2</a></li>
<li><a href="NFATC3" title="NFATC3">C3</a></li>
<li><a href="NFATC4" title="NFATC4">C4</a></li>
<li><a href="NFAT5" title="NFAT5">5</a></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.2)</i> <a href="STAT_protein" title="STAT protein">STAT</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">
<ul><li><a href="STAT_protein" title="STAT protein">STAT</a>
<ul><li><a href="STAT1" title="STAT1">1</a></li>
<li><a href="STAT2" title="STAT2">2</a></li>
<li><a href="STAT3" title="STAT3">3</a></li>
<li><a href="STAT4" title="STAT4">4</a></li>
<li><a href="STAT5" title="STAT5">5</a></li>
<li><a href="STAT6" title="STAT6">6</a></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.3) p53-like</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><a href="P53_p63_p73_family" title="P53 p63 p73 family">p53 p63 p73 family</a>
<ul><li><a href="P53" title="P53">p53</a></li>
<li><a href="TP63" title="TP63">TP63</a></li>
<li><a href="P73" title="P73">p73</a></li></ul></li>
<li><a href="T-box" title="T-box">TBX</a>
<ul><li><a href="TBX1" title="TBX1">1</a></li>
<li><a href="TBX2" title="TBX2">2</a></li>
<li><a href="TBX3" title="TBX3">3</a></li>
<li><a href="TBX5_(gene)" title="TBX5 (gene)">5</a></li>
<li><a href="TBX19" title="TBX19">19</a></li>
<li><a href="TBX21" title="TBX21">21</a></li>
<li><a href="TBX22" title="TBX22">22</a></li>
<li><a href="TBR1" title="TBR1">TBR1</a></li>
<li><a href="Eomesodermin" title="Eomesodermin">TBR2</a></li>
<li><a href="Brachyury" class="mw-redirect" title="Brachyury">TFT</a></li></ul></li>
<li><a href="Myelin_regulatory_factor" title="Myelin regulatory factor">MYRF</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.4)</i> <a href="MADS-box" title="MADS-box">MADS box</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Mef2" title="Mef2">Mef2</a>
<ul><li><a href="Myocyte-specific_enhancer_factor_2A" title="Myocyte-specific enhancer factor 2A">A</a></li>
<li><a href="MEF2B" title="MEF2B">B</a></li>
<li><a href="MEF2C" title="MEF2C">C</a></li>
<li><a href="MEF2D" title="MEF2D">D</a></li></ul></li>
<li><a href="Serum_response_factor" title="Serum response factor">SRF</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.6)</i> <a href="TATA-binding_protein" title="TATA-binding protein">TATA-binding proteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><a href="TATA-binding_protein" title="TATA-binding protein">TBP</a></li>
<li><a href="TBPL1" title="TBPL1">TBPL1</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.7)</i> <a href="High-mobility_group" title="High-mobility group">High-mobility group</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">
<ul><li><a href="BBX_(gene)" title="BBX (gene)">BBX</a></li>
<li><a href="HMG-box" title="HMG-box">HMGB</a>
<ul><li><a href="HMGB1" title="HMGB1">1</a></li>
<li><a href="HMGB2" title="HMGB2">2</a></li>
<li><a href="HMGB3" title="HMGB3">3</a></li>
<li><a href="HMGB4" title="HMGB4">4</a></li></ul></li>
<li><a href="HMGN" title="HMGN">HMGN</a>
<ul><li><a href="HMGN1" title="HMGN1">1</a></li>
<li><a href="HMGN2" title="HMGN2">2</a></li>
<li><a href="HMGN3" title="HMGN3">3</a></li>
<li><a href="HMGN4" title="HMGN4">4</a></li></ul></li>
<li><i>HNF</i>
<ul><li><a href="HNF1A" title="HNF1A">1A</a></li>
<li><a href="HNF1B" title="HNF1B">1B</a></li></ul></li>
<li><a href="SOX_gene_family" title="SOX gene family">SOX</a>
<ul><li><a href="SOX1" title="SOX1">1</a></li>
<li><a href="SOX2" title="SOX2">2</a></li>
<li><a href="SOX3" title="SOX3">3</a></li>
<li><a href="SOX4" title="SOX4">4</a></li>
<li><a href="SOX5" title="SOX5">5</a></li>
<li><a href="SOX6" title="SOX6">6</a></li>
<li><a href="SOX8" title="SOX8">8</a></li>
<li><a href="SOX9" title="SOX9">9</a></li>
<li><a href="SOX10" title="SOX10">10</a></li>
<li><a href="SOX11" title="SOX11">11</a></li>
<li><a href="SOX12" title="SOX12">12</a></li>
<li><a href="SOX13" title="SOX13">13</a></li>
<li><a href="SOX14" title="SOX14">14</a></li>
<li><a href="SOX15" title="SOX15">15</a></li>
<li><a href="SOX17" title="SOX17">17</a></li>
<li><a href="SOX18" title="SOX18">18</a></li>
<li><a href="SOX21" title="SOX21">21</a></li></ul></li>
<li><a href="Testis_determining_factor" class="mw-redirect" title="Testis determining factor">SRY</a></li>
<li><a href="Structure_specific_recognition_protein_1" title="Structure specific recognition protein 1">SSRP1</a></li>
<li><a href="TCF/LEF_family" title="TCF/LEF family">TCF/LEF</a>
<ul><li><i>TCF</i>
<ul><li><a href="TCF7" title="TCF7">1</a></li>
<li><a href="TCF7L2" title="TCF7L2">4</a></li></ul></li>
<li><a href="Lymphoid_enhancer-binding_factor_1" title="Lymphoid enhancer-binding factor 1">LEF1</a></li></ul></li>
<li><i>TOX</i>
<ul><li><a href="TOX" title="TOX">1</a></li>
<li><a href="TOX2" title="TOX2">2</a></li>
<li><a href="TOX3" title="TOX3">3</a></li>
<li><a href="TOX4" title="TOX4">4</a></li></ul></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.9) Grainyhead</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><a href="TFCP2" title="TFCP2">TFCP2</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.10) Cold-shock domain</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">
<ul><li><a href="CSDA_(gene)" title="CSDA (gene)">CSDA</a></li>
<li><a href="Y_box_binding_protein_1" title="Y box binding protein 1">YBX1</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.11) Runt</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><a href="Core_binding_factor" title="Core binding factor">CBF</a>
<ul><li><a href="CBFA2T2" title="CBFA2T2">CBFA2T2</a></li>
<li><a href="CBFA2T3" title="CBFA2T3">CBFA2T3</a></li>
<li><a href="RUNX1" title="RUNX1">RUNX1</a></li>
<li><a href="RUNX2" title="RUNX2">RUNX2</a></li>
<li><a href="RUNX3" title="RUNX3">RUNX3</a></li>
<li><a href="RUNX1T1" title="RUNX1T1">RUNX1T1</a></li></ul></li></ul>
</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(0)_Other_transcription_factors178" style="font-size:114%;margin:0 4em"><i> (0) Other transcription factors</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.2) HMGI(Y)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><a href="HMGA" title="HMGA">HMGA</a>
<ul><li><a href="HMGA1" title="HMGA1">1</a></li>
<li><a href="HMGA2" title="HMGA2">2</a></li></ul></li>
<li><a href="HBP1" title="HBP1">HBP1</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.3)</i> <a href="Pocket_protein_family" title="Pocket protein family">Pocket domain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">
<ul><li><a href="Retinoblastoma_protein" title="Retinoblastoma protein">Rb</a></li>
<li><a href="Retinoblastoma-like_protein_1" title="Retinoblastoma-like protein 1">RBL1</a></li>
<li><a href="Retinoblastoma-like_protein_2" title="Retinoblastoma-like protein 2">RBL2</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.5)</i> <a href="Apetala_2" title="Apetala 2">AP-2</a><i>/</i><a href="Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a><i>-related factors</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em">
<ul><li><a href="Apetala_2" title="Apetala 2">Apetala 2</a></li>
<li><a href="Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a></li>
<li><a href="B3_domain" title="B3 domain">B3</a></li></ul>
</div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.6) Miscellaneous</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">
<ul><li><i>ARID</i>
<ul><li><a href="ARID1A" title="ARID1A">1A</a></li>
<li><a href="ARID1B" title="ARID1B">1B</a></li>
<li><a href="ARID2" title="ARID2">2</a></li>
<li><a href="ARID3A" title="ARID3A">3A</a></li>
<li><a href="ARID3B" title="ARID3B">3B</a></li>
<li><a href="ARID4A" title="ARID4A">4A</a></li></ul></li>
<li><a href="Catabolite_activator_protein" title="Catabolite activator protein">CAP</a></li>
<li><i>IFI</i>
<ul><li><a href="IFI16" title="IFI16">16</a></li>
<li><a href="IFI35" title="IFI35">35</a></li></ul></li>
<li><a href="MLL_(gene)" class="mw-redirect" title="MLL (gene)">MLL</a>
<ul><li><a href="MLL2" class="mw-redirect" title="MLL2">2</a></li>
<li><a href="MLL3" class="mw-redirect" title="MLL3">3</a></li>
<li><a href="MLLT1" title="MLLT1">T1</a></li></ul></li>
<li><a href="MNDA" title="MNDA">MNDA</a></li>
<li><i>NFY</i>
<ul><li><a href="NFYA" title="NFYA">A</a></li>
<li><a href="NFYB" title="NFYB">B</a></li>
<li><a href="NFYC" title="NFYC">C</a></li></ul></li>
<li><a href="Rho_factor" title="Rho factor">Rho</a>/<a href="Sigma_factor" title="Sigma factor">Sigma</a></li></ul>
</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><i>see also transcription factor/coregulator deficiencies</i></div></td></tr></tbody></table></div>
<p><i>This article incorporates text from the <a href="United_States_National_Library_of_Medicine" title="United States National Library of Medicine">United States National Library of Medicine</a>, which is in the <a href="Public_domain" title="Public domain">public domain</a>.</i>
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